Bcr-abl small molecule myristate inhibitors and methods of use

摘要

A compound selected from the following: 4- (6- (4- (trifluoromethoxy) phenylamino) -5-methylpyrimidin-4-yl) -N- (2-morpholinoethyl) benzamide; 6- (1H-pyrrolo [2,3-b] pyridin-1-yl) -N- (4- (trifluoromethoxy) phenyl) pyrimidin-4-amine; N- (4- (trifluoromethoxy) phenyl) -6- (1,3,5-trimethyl-1 H -pyrazol-4-yl) pyrimidin-4-amine; 4- [5-Methyl-6- (4-trifluoromethoxy-phenylamino) -pyrimidin-4-yl] -benzenesulfonamide; N-Methyl-4- [5-methyl-6- (4-trifluoromethoxy-phenylamino) -pyrimidin-4-yl] -benzenesulfonamide; N-Ethyl-4- [6- (4-trifluoromethoxy-phenylamino) -pyrimidin-4-yl] -benzenesulfonamide; N- (2-Hydroxy-ethyl) -4- [6- (4-trifluoromethoxy-phenylamino) -pyrimidin-4-yl] -benzenesulfonamide; [6- (4-Methanesulfonyl-phenyl) -pyrimidin-4-yl] - (4-trifluoromethoxy-phenyl) -amine; [6- (4-Methanesulfonyl-phenyl) -5-methyl-pyrimidin-4-yl] - (4-trifluoromethoxyphenyl) -amine; {6- [4- (Propane-2-sulfonyl) -phenyl] -pyrimidin-4-yl} - (4-trifluoromethoxy-phenyl) -amine; {5-Methyl-6- [4- (propane-2-sulfonyl) -phenyl] -pyrimidin-4-yl} - (4-trifluoromethoxy-phenyl) -amine; N, N-Diethyl-4- [6- (4-trifluoromethoxy-phenylamino) -pyrimidin-4-yl] -benzenesulfonamide; N, N-Diethyl-4- [5-methyl-6- (4-trifluoromethoxy-phenylamino) -pyrimidin-4-yl] -benzenesulfonamide; {6- [4- (Piperidine-1-sulfonyl) -phenyl] -pyrimidin-4-yl} - (4-trifluoromethoxy-phenyl) -amine; 4-Methyl-N- {4- [6- (4-trifluoromethoxy-phenylamino) -pyrimidin-4-yl] -phenyl} -benzenesulfonamide; 4-Methyl-N- {4- [5-methyl-6- (4-trifluoromethoxy-phenylamino) -pyrimidin-4-yl] -phenyl} -benzenesulfonamide; N- {4- [6- (4-Trifluoromethoxy-phenylamino) -pyrimidin-4-yl] -phenyl} -methanesulfonamide; Ethanesulfonic acid {4- [6- (4-trifluoromethoxy-phenylamino) -pyrimidin-4-yl] -phenyl} -amide; Butane-1-sulfonic acid {4- [6- (4-trifluoromethoxy-phenylamino) -pyrimidin-4-yl] -phenyl} -amide; Propane-2-sulfonic acid {4- [6- (4-trifluoromethoxy-phenylamino) -pyrimidin-4-yl] -phenyl} -amide; Pentane-2-sulfonic acid {4- [6- (4-trifluoromethoxy-phenylamino) -pyrimidin-4-yl] -phenyl} -amide; N- (2-Hydroxy-ethyl) -4- [5-methyl-6- (4-trifluoromethoxy-phenylamino) -pyrimidin-4-yl] -benzamide; 4- [5-Methyl-6- (4-trifluoromethoxy-phenylamino) -pyrimidin-4-yl] -N- (2-morpholin-4-yl-ethyl) -benzamide; N- (3-Methoxy-propyl) -4- [5-methyl-6- (4-trifluoromethoxy-phenylamino) -pyrimidin-4-yl] -benzamide; N- {3- [5-Methyl-6- (4-trifluoromethoxy-phenylamino) -pyrimidin-4-yl] -phenyl} -acetamide; 3- [5-Methyl-6- (4-trifluoromethoxy-phenylamino) -pyrimidin-4-yl] -benzamide; 3- [5-methyl-6- (4-trifluoromethoxy-phenylamino) -pyrimidin-4-yl] -benzoic acid; (6-Biphenyl-4-yl-pyrimidin-4-yl) - (4-trifluoromethoxy-phenyl) -amine; (6-Biphenyl-4-yl-5-methyl-pyrimidin-4-yl) - (4-trifluoromethoxy-phenyl) -amine; [6- (5-Methoxy-naphthalen-2-yl) -pyrimidin-4-yl] - (4-trifluoromethoxy-phenyl) -amine; [6- (5-Methoxy-naphthalen-2-yl) -5-methyl-pyrimidin-4-yl] - (4-trifluoromethoxyphenyl) -amine; {3- [6- (4-Trifluoromethoxy-phenylamino) -pyrimidin-4-yl] -phenyl} -acetonitrile; [6- (3-Nitro-phenyl) -pyrimidin-4-yl] - (4-trifluoromethoxy-phenyl) -amine; 4-Methoxy-N- {4- [6- (4-trifluoromethoxy-phenylamino) -pyrimidin-4-yl] -phenyl} -benzamide; [6- (4-Aminomethyl-phenyl) -5-methyl-pyrimidin-4-yl] - (4-trifluoromethoxy-phenyl) -amine; 5-Bromo-N- (2-morpholin-4-yl-ethyl) -N '- (4-trifluoromethoxy-phenyl) -pyrimidine-4,6-diamine; 1- [5-Bromo-6- (4-trifluoromethoxy-phenylamino) -pyrimidin-4-yl] -piperidine-3-carboxylic acid amide; {6- [2- (2-Morpholin-4-yl-ethylamino) -imidazol-1-yl] -pyrimidin-4-yl} - (4-trifluoromethoxy-phenyl) -amine; (4-Trifluoromethoxy-phenyl) - {6- [2- (4-trifluoromethoxy-phenylamino) -imidazol-1-yl] -pyrimidin-4-yl} -amine; N- (5-Cyclopropyl-1H-pyrazol-3-yl) -N '- (4-trifluoromethoxy-phenyl) -pyrimidine-4,6-diamine; [6- (3-Amino-5-cyclopropyl-pyrazol-1-yl) -pyrimidin-4-yl] - (4-trifluoromethoxy-phenyl) -amine; N- (4-Trifluoromethoxy-phenyl) -N '- [1- (3-trifluoromethyl-phenyl) -1H-imidazol-2-yl] -pyrimidine-4,6-diamine; (6-Pyrrolo [2,3-b] pyridin-1-yl-pyrimidin-4-yl) - (4-trifluoromethoxy-phenyl) -amine; [6- (1H-Pirazol-4-yl) -pyrimidin-4-yl] - (4-trifluoromethoxy-phenyl) -amine; [6- (1-Methyl-1H-pyrazol-4-yl) -pyrimidin-4-yl] - (4-trifluoromethoxy-phenyl) -amine; [6- (1-Isobutyl-1H-pyrazol-4-yl) -pyrimidin-4-yl] - (4-trifluoromethoxy-phenyl) -amine; [6- (1-Isobutyl-1H-pyrazol-4-yl) -5-methyl-pyrimidin-4-yl] - (4-trifluoromethoxy-phenyl) -amine; (4-Trifluoromethoxy-phenyl) - [6- (1,3,5-trimethyl-1 H -pyrazol-4-yl) -pyrimidin-4-yl] -amine; {6- [1- (4-Methanesulfonyl-benzyl) -1H-pyrazol-4-yl] -pyrimidin-4-yl} - (4-trifluoromethoxy-phenyl) -amine; [6- (1-Etanosulfonyl-1H-pyrazol-4-yl) -pyrimidin-4-yl] - (4-trifluoromethoxy-phenyl) -amine; [6- (1-Pyridin-4-ylmethyl-1 H -pyrazol-4-yl) -pyrimidin-4-yl] - (4-trifluoromethoxy-phenyl) -amine; N6- (2-Morpholin-4-yl-ethyl) -N6 '- (4-trifluoromethoxy-phenyl) - [4,4'] bipyrimidinyl-6,6'-diamine; [5-Methyl-6- (1-methyl-1H-pyrazol-4-yl) -pyrimidin-4-yl] - (4-trifluoromethoxy-phenyl) -amine; [6- (5-Methyl-1-phenyl-1H-pyrazol-4-yl) -pyrimidin-4-yl] - (4-trifluoromethoxy-phenyl) -amine; [5-Methyl-6- (5-methyl-1-phenyl-1H-pyrazol-4-yl) -pyrimidin-4-yl] - (4-trifluoromethoxy-phenyl) -amine; [6- (1H-Indol-4-yl) -pyrimidin-4-yl] - (4-trifluoromethoxy-phenyl) -amine; [6- (1H-Indol-3-yl) -pyrimidin-4-yl] - (4-trifluoromethoxy-phenyl) -amine; [6- (1H-Indol-5-yl) -pyrimidin-4-yl] - (4-trifluoromethoxy-phenyl) -amine; 4- [6- (4-Trifluoromethoxy-phenylamino) -pyrimidin-4-yl] -furan-2-carbaldehyde; (6-Benzo [b] thiophen-4-yl-pyrimidin-4-yl) - (4-trifluoromethoxy-phenyl) -amine; [6- (1H-Indol-4-yl) -5-methyl-pyrimidin-4-yl] - (4-trifluoromethoxy-phenyl) -amine; (6-Dibenzofuran-4-yl-pyrimidin-4-yl) - (4-trifluoromethoxy-phenyl) -amine; [6- (1-Benzyl-1 H -pyrazol-4-yl) -pyrimidin-4-yl] - (4-trifluoromethoxy-phenyl) -amine; [6- (1-Benzyl-1H-pyrazol-4-yl) -5-methyl-pyrimidin-4-yl] - (4-trifluoromethoxy-phenyl) -amine; N6, N6'-Bis- (4-trifluoromethoxy-phenyl) - [4,4 '] bipyrimidinyl-6,6'-diamine; N6- (2-Morpholin-4-yl-ethyl) -N6 '- (4-trifluoromethoxy-phenyl) - [4,4'] bipyrimidinyl-6,6'-diamine; N- (4-Methyl-3- {1- [6- (4-trifluoromethoxy-phenylamino) -pyrimidin-4-yl] -1 H -imidazol-2-ylamino} -phenyl) -benzamide; N- (4-Methyl-3- {1- [6- (4-trifluoromethoxy-phenylamino) -pyrimidin-4-yl] -1H-imidazol-2-ylamino} -phenyl) -4-morpholin-4-ylmethyl- 3- trifluoromethyl-benzamide; [6- (1-Pyridin-3-ylmethyl-1 H -pyrazol-4-yl) -pyrimidin-4-yl] - (4-trifluoromethoxy-phenyl) -amine; [6- (1H-Pyrrolo [2,3-b] pyridin-4-yl) -pyrimidin-4-yl] - (4-trifluoromethoxy-phenyl) -amine; 4- [6- (4-Trifluoromethoxy-phenylamino) -pyrimidin-4-yl] -1H-pyridin-2-one; [6- (2-Methyl-thiazol-4-yl) -pyrimidin-4-yl] - (4-trifluoromethoxy-phenyl) -amine; 2-Fluoro-5- [6- (4-trifluoromethoxy-phenylamino) -pyrimidin-4-yl] -benzaldehyde; {6- [2- (4-Methyl-piperazin-1-yl) -pyridin-4-yl] -pyrimidin-4-yl} - (4-trifluoromethoxyphenyl) -amine, or a pharmaceutically acceptable salt, solvate or hydrate of same.