Variants of Factor IX with coagulant activity in the absence of its cofactor and its use for the treatment of bleeding disorders

摘要

A variant of factor IX (F. IX) or activated factor IX (F. IXa), which is characterized in that it has coagulant activity in the absence of its cofactor, in which the cofactor is factor VIII (F. VIII) or the activated factor VIII (F. VIIIa), which comprises at least one amino acid substitution at position 265 in combination with amino acid substitution 1383V and amino acid substitution V181I.