D-serine transporter inhibitors as pharmaceutical compositions for the treatment of central nervous system disorders

摘要

An acceptable pharmaceutical composition containing a therapeutically effective amount of one or more D-serine transporter inhibitor compounds for use in a method for the treatment of disorders of the central nervous system caused by a deficiency in the function of the N-methyl receptor. D-aspartate wherein said one or more D-serine transporter inhibitor compounds is selected from L-gamma-glutamyl-4- nitroanilide, L-4-fluorophenylglycine, trans-4-hydroxy-L-proline and R-gamma-2, 4-dichlorobenzyl-L-proline and where the nervous system disorder is schizophrenia, schizophreniform disorder and schizoaffective disorder and conditions specifically selected from the following: behavior disorder, aggressive solitary type, behavioral disorder, undifferentiated type, disorder de la Tourette, chronic motor disorder or vocal tic disorder, transient tic disorder, tic disorder, alcohol withdrawal, delirium, alu alcoholic cyanosis, alcoholic dementia due to alcoholism, sympathomimetic poisoning by amphetamine or similar action, sympathomimetic delirium due to amphetamine or similar action, delusional sympathomimetic disorder due to amphetamine or similar action, delusional marijuana disorder, cocaine intoxication, cocaine delirium cocaine delusional, hallucinogenic hallucinosis, hallucinogenic delusional disorder, hallucinogenic mood disorder, post-hallucinogenic perceptual disorder, similarly acting phencyclidine or arylcyclohexylamine poisoning, phenycylidine or arylcyclohexylamine delirium, similar acting disorder arylcyclohexylamine of similar action, mood disorder caused by phencyclidine or arylcyclohexylamine of similar action, organic mental disorder due to phencyclidine or arylcyclohexylamine of similar action, poisoning with other substances psychoactive or unspecified, delirium from other psychoactive or unspecified substances, dementia from other psychoactive or unspecified substances, delusional disorder from other psychoactive or unspecified substances, hallucinosis from other psychoactive or unspecified substances, mood disorder from other substances psychoactive or unspecified, anxiety disorder due to other psychoactive or unspecified substances, personality disorder due to other psychoactive or unspecified substances, organic mental disorder due to other psychoactive or unspecified substances, delirium, dementia, delusional organic disorder, organic hallucinosis, organic mood disorder, organic anxiety disorder, organic personality disorder, mental mental disorder, obsessive compulsive disorder, posttraumatic stress disorder, generalized anxiety disorder, anxiety disorder, body dysmorphic disorder, hip ochondriasis (or hypochondriacal neurosis), somatization disorder, undifferentiated somatomorphic disorder, somatomorphic disorder, intermittent explosive disorder, kleptomania, ludopathy, pyromania, trichotillomania, and impulse control disorder, catatonic, subchronic schizophrenia, catatonic cataract, chronic catatonic subchronic with acute worsening, catatonic schizophrenia, chronic, with acute worsening, catatonic schizophrenia, in remission, catatonic schizophrenia, unspecified, disorganized schizophrenia, subchronic, disorganized schizophrenia, chronic, disorganized schizophrenia, subchronic with acute worsening, chronic disorganization, schizophrenia acute, disorganized schizophrenia, in remission, disorganized, unspecified schizophrenia, subchronic paranoid schizophrenia, chronic paranoid schizophrenia, paranoid schizophrenia, subchronic with acute worsening, paranoid schizophrenia, Chronic with acute worsening, paranoid schizophrenia, in remission, paranoid schizophrenia, unspecified, undifferentiated, subchronic schizophrenia, undifferentiated schizophrenia, chronic, undifferentiated schizophrenia, subchronic with acute worsening, undifferentiated schizophrenia, chronic worsening in acute distress, schizophrenia undifferentiated, unspecified, residual schizophrenia, subchronic, residual schizophrenia, chronic, schizophrenia, residual, subchronic with acute worsening, residual schizophrenia, chronic with acute worsening, residual schizophrenia, in remission, residual schizophrenia, subchronic, residual schizophrenia, chronic, residual schizophrenia , subchronic with acute worsening, schizophrenia, residual, chronic with acute worsening, schizophrenia, residual, in remission, schizophrenia, residual, unspecified, delusional disorder (paranoid), psi schizophrenia-shaped disorder brief reactive cosis, provoked psychotic disorder, psychotic disorder (atypical psychosis), personality disorders, paranoid, personality disorders, schizoid personality disorders, personality disorders, schizoid type, personality disorders, antisocial and personality disorders, intermediate