1,3-Dihydro-2H-benzimidazol-2-one derivatives substituted with heterocycles as antiviral agents for the respiratory syncytial virus

摘要

A compound formula (I), ** Formula ** or a stereoisomeric form thereof, wherein Het is a heterocycle having the formula (c-1a) ** Formula ** R3c is H; R2c is - (CR 10 8R9) m-R10c where R8 and R9 are each H, m is 3 and R10c represents CN or SO2CH3; R4 is selected from the group consisting of aryl; the aryl is phenyl substituted with two substituents each independently selected from the group consisting of halo, C1-C4 alkyloxy or C1-C4 alkyl; each of R8 and R9 is independently selected from the group consisting of H, C1-C10 alkyl and C3-C7 cycloalkyl; Z is N and R5 is absent; or a pharmaceutically acceptable salt or solvate thereof.