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IDENTIFICATION OF A MICRO-RNA THAT ACTIVATES EXPRESSION OF .BETA.-MYOSIN HEAVY CHAIN
IDENTIFICATION OF A MICRO-RNA THAT ACTIVATES EXPRESSION OF .BETA.-MYOSIN HEAVY CHAIN
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机译:激活β-肌球蛋白重链表达的微RNA的鉴定
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摘要
The present invention relates to the identification of a microRNA, miR-208, that induces the expression of .beta.-myosin heavy chain (.beta.-MHC) and represses fast skeletal muscle contractile protein genes. Inhibition of this function is proposed as a treatment for cardiac fibrosis, hypertrophy and/or heart failure, and augmentation of this function can be used to repress slow fiber genes and activate fast fiber genes in the treatment of musculoskeletal disorders.
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