IN VIVO PHOTOACOUSTIC AND PHOTOTHERMAL NANO-THERANOSTICS OF BIOFILMS

摘要

A composition and methods for the non-invasive destruction of bacteria cells in vivo using a combination therapy of antibiotics and photothermal nano-theranostics. In one aspect, a composition and method for destroying at least one bacteria cell using a functionalized PA contrast agent with a targeting agent, coating, and antibiotic that uses photoacoustic signals to create thermal energy and release the loaded antibiotic are described.