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MONOCLONAL ANTIBODIES SPECIFICALLY FOR THE ANTIGEN P OF THE HUMAN RESPIRATORY SYNCYTIAL VIRUS, PRODUCED AND SECRETED BY THE CELLS HYBRIDOMAS, USEFUL FOR DETECTION AND DIAGNOSTIC OF THE INFECTION CAUSED BY RSV
MONOCLONAL ANTIBODIES SPECIFICALLY FOR THE ANTIGEN P OF THE HUMAN RESPIRATORY SYNCYTIAL VIRUS, PRODUCED AND SECRETED BY THE CELLS HYBRIDOMAS, USEFUL FOR DETECTION AND DIAGNOSTIC OF THE INFECTION CAUSED BY RSV
The present invention refers to monoclonal antibodies or fragments thereof which are binding to the protein P of the human Respiratory Syncytial Virus (RSV) which comprise a variable region of the heavy chain which has a sequence with at least a 90%, 95% or 99% of identity with the SEQ ID No: 1 or SEQ ID 5 or a variable region of the light chain which has a sequence with at least a 90%, 95% or 99% of identity with the SEQ ID No:2 or SEQ ID No: 6. The invention provides also diagnostic methods ex vivo or in vitro for detection of the viral antigen P of RSV, in which are used the monoclonal antibodies produced and secreted by the hybridomas 2E6/D2 and 6H5/H1. The invention can be used in detection for RSV kits, comprising the antibodies produced by the mentioned hybridomas.
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机译:本发明涉及与人呼吸道合胞病毒(RSV)的蛋白P结合的单克隆抗体或其片段,其包含重链的可变区,该可变区的序列具有至少90%,95%或99的序列。与SEQ ID No:1或SEQ ID 5或具有与SEQ ID No:2或SEQ ID至少90%,95%或99%相同的序列的轻链可变区No:6。本发明还提供了离体或体外诊断RSV病毒抗原P的诊断方法,其中使用了由杂交瘤2E6 / D2和6H5 / H1产生和分泌的单克隆抗体。本发明可用于检测RSV试剂盒,其包含由所述杂交瘤产生的抗体。
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