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COMPOSITION FOR INDUCING DIFFERENTIATION OF HUMAN PLURIPOTENT STEM CELLS INTO MYOCARDIAL CELLS
COMPOSITION FOR INDUCING DIFFERENTIATION OF HUMAN PLURIPOTENT STEM CELLS INTO MYOCARDIAL CELLS
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机译:用于诱导人多能干细胞向心肌细胞分化的组合物
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摘要
Disclosed is a small molecule compound composition that efficiently induces the differentiation of human pluripotent stem cells into myocardial cells. In particular, provided in the present invention is a small molecule compound composition. The small molecule compound composition comprises the following components: (i) an mTOR signaling pathway inhibitor; (ii) a Wnt pathway promoter; and (iii) optionally, a pharmaceutically acceptable carrier. The small molecule compound composition in the present invention can efficiently induce the differentiation of human pluripotent stem cells into myocardial cells. The preliminarily screened cardiomyocyte differentiation rate reaches up to 86%, and the optimized cardiomyocyte differentiation rate reaches up to 98.3%.
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