TRUNCATED GLYCOPROTEIN G OF HERPES SIMPLEX VIRUS 2

摘要

The present invention relates to a protein comprising a truncated version of the HSV- 2 protein mg G-2, said protein comprising: (i) an extracellular region of mg G-2 (EX-mg G-2), or a truncated version thereof, of at least 285 amino acids; said extracellular region or truncated version thereof having at least 90 %, 95 %, 96 %, 97 %, 98 % or 99 % sequence identity (%SI) to a peptide fragment of the corresponding length present in SEQ ID NO: 3; (ii) a truncated transmembrane region of mg G-2 (t-TMR-mg G-2) of 2 to 15 amino acids; said truncated transmembrane region having at least 90 % sequence identity (%SI) to a peptide fragment of the corresponding length present in SEQ ID NO: 6; and (iii) an intracellular region of mg G-2 (IC-mg G-2), or a truncated version thereof, of at least 18 amino acids; said intracellular region or truncated version thereof having at least 90 % or 95 % sequence identity (%SI) to a peptide fragment of the corresponding length present in SEQ ID NO: 8.