首页> 外国专利> PREVENTING OR TREATING VIRAL INFECTION BY INHIBITION OF THE HISTONE METHYLTRANSFERASE EZH1 OR EZH2

PREVENTING OR TREATING VIRAL INFECTION BY INHIBITION OF THE HISTONE METHYLTRANSFERASE EZH1 OR EZH2

机译:通过抑制组蛋白甲基转移酶EZH1或EZH2来预防或治疗病毒感染

摘要

Disclosed are methods of preventing or treating a viral infection of a host, the method comprising administering to the host an effective amount of an inhibitor of the histone methyltransferase activity of EZH1 or EZH2. In one embodiment, the method comprises administering to the host an effective amount of a compound of Formula (I): wherein X1, X2, R1, R2, and R3 are defined herein; or pharmaceutically acceptable salts, solvates, or stereoisomers thereof. In another embodiment, the present invention provides a method of inhibiting an EZH1 or EZH2 methyltransferase in a virus-infected host, the method comprising administering to the host an effective amount of a compound of Formula (I) as defined above. In another embodiment, the present invention provides a method of improving the therapeutic effect of a pharmaceutical composition, the method comprising adding to the pharmaceutical composition a compound of Formula (I) as defined above.
机译:公开了预防或治疗宿主的病毒感染的方法,该方法包括向宿主施用有效量的EZH1或EZH2的组蛋白甲基转移酶活性的抑制剂。在一个实施方案中,该方法包括向宿主施用有效量的式(I)的化合物:其中X 1 ,X 2 ,R 1 < / Sup>,R 2 和R 3 在此定义;或其药学上可接受的盐,溶剂化物或立体异构体。在另一个实施方案中,本发明提供了一种在病毒感染的宿主中抑制EZH1或EZH2甲基转移酶的方法,该方法包括向宿主施用有效量的如上定义的式(I)的化合物。在另一个实施方案中,本发明提供了改善药物组合物的治疗效果的方法,该方法包括向药物组合物中添加如上定义的式(I)的化合物。

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