CHOLIC ACID MODIFIED GLUCOSAMINE DERIVATIVE AND PREPARATION METHOD AND USE

摘要

The present invention relates to a cholic acid modified glucosamine derivative and a preparation method and use therefor, the derivative being as shown in formula (I), wherein R1 is H or OH, R2 is H or OH, R3 is H, CH2 = CHCO- or CH2 = C(CH3)CO-. In the presence of a carbodiimide condensation reagent, reacting the cholic acid with excess acid N- hydroxysuccinimide or 1-hydroxybenzotriazole generates an cholic acid active ester, and then reacting with D- glucosamine to obtain a derivative without polymerizable groups; or first reacting the cholic acid active ester with acyl chloride containing vinyl, and then reacting with D- glucosamine to obtain a derivative with polymerizable groups. The derivative of the present invention has a good biocompatibility, the derivative without polymerizable groups can be used as a medicine for the treatment of osteoarthritis, and the derivative with polymerizable groups is an organic matrix for a cartilage prosthesis material, or for constructing in situ molded glucosamine functional hydrogels.