首页> 外国专利> POTENTIATED T-CELL MODULATOR ABLE TO MODULATE IMMUNE RESPONSE, METHOD FOR EXTRACTING, TESTING AND COUNTING A DIALYSABLE LEUCOCYTE EXTRACT FROM SHARK SPLEEN TO PRODUCE SAME, AND THERAPEUTIC USE THEREOF

POTENTIATED T-CELL MODULATOR ABLE TO MODULATE IMMUNE RESPONSE, METHOD FOR EXTRACTING, TESTING AND COUNTING A DIALYSABLE LEUCOCYTE EXTRACT FROM SHARK SPLEEN TO PRODUCE SAME, AND THERAPEUTIC USE THEREOF

机译：能够调节免疫反应的电位T细胞调节剂，从鲨鱼脾中提取，检测和计数可透析的白细胞提取物以生产相同方法的方法及其治疗用途

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摘要

The present invention relates to a potentiated T-cell modulator (TCM), with a potency of 10¹² leucocytes/mm³, obtained from a dialysed extract of leucocytes from the spleen of Selachimorpha or sharks that contains peptides equal to or less than 10,000 Da, in powder form. The invention also relates to the use of the TCM to produce a medicine for treating diseases related to the regulation of immune response such as cancer or viral infections.

机译：本发明涉及一种增强的T细胞调节剂（TCM），其从脾脏的白细胞的透析提取物中获得的效价为10 ^{12 白细胞/ mm ^{3 。含有等于或小于10,000 Da肽的粉末状 Selachimorpha 或鲨鱼。本发明还涉及中药在制备用于治疗与免疫应答调节有关的疾病例如癌症或病毒感染的药物中的用途。}} 展开▼

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公开/公告号WO2016195470A1

专利类型

公开/公告日2016-12-08

原文格式PDF

申请/专利权人 ZEPEDA LÓPEZ HECTOR MANUEL;
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申请/专利号WO2015MX00088

发明设计人 ZEPEDA LÓPEZ HECTOR MANUEL;
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申请日2015-06-04

分类号A61K35/60;A61K38/02;A61P37/02;

国家 WO

入库时间 2022-08-21 13:33:40

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1. 小牛脾提取物及在原发免疫性血小板减少症治疗中的用途 [P] . 中国专利： CN104352520B . 2018.05.22

2. 小牛脾提取物及在原发免疫性血小板减少症治疗中的用途 [P] . 中国专利： CN104352520A . 2015-02-18

3. POTENTIATED T-CELL MODULATOR ABLE TO MODULATE IMMUNE RESPONSE, METHOD FOR EXTRACTING, TESTING AND COUNTING A DIALYSABLE LEUCOCYTE EXTRACT FROM SHARK SPLEEN TO PRODUCE SAME, AND THERAPEUTIC USE THEREOF. [P] . MX2017015704A . 2019-06-25

机译：能够调节免疫反应的电位T细胞调节剂，从鲨鱼脾脏中提取，检测和计数可透析的白细胞提取物以生产相同方法的方法，以及用于治疗的方法。

4. (EN) POTENTIATED T-CELL MODULATOR ABLE TO MODULATE IMMUNE RESPONSE, METHOD FOR EXTRACTING, TESTING AND COUNTING A DIALYSABLE LEUCOCYTE EXTRACT FROM SHARK SPLEEN TO PRODUCE SAME, AND THERAPEUTIC USE THEREOF [P] . 美国专利： US2018264050A1 . 2018-09-20

机译：（ZH）能够调节免疫反应的电位T细胞调节剂，从鲨鱼脾脏中提取，检测和计数可疑白细胞提取物以产生相同成分的方法，以及用于治疗的方法

5. compound, stable antibody-producing cell line, composition, methods for modulating an immune response in an individual and for treating and / or preventing disease, uses of a compound and / or composition and dendritic cells or precursors thereof, methods to enrich and detect dendritic cells or a subset or precursors thereof, polypeptide, vector polynucleotide, host cell, transgenic plant, transgenic non-human animal, extract, process for preparing a compound or polypeptide, enriched dendritic cell population and / or precursors expanded dendritic cell population and / or precursors thereof, methods for identifying a molecule that binds to a polypeptide and screening for a compound that binds to a polypeptide, use of a polypeptide, a polynucleotide, a vector , a host cell, a transgenic plant, an extract, a cell population and / or a composition. tion, method for producing a compound, and kit. [P] . BRPI0815848A2 . 2017-06-06

机译：化合物，稳定的抗体产生细胞系，组合物，调节个体免疫应答和治疗和/或预防疾病的方法，化合物和/或组合物和树突状细胞或其前体的用途，富集和检测树突状细胞的方法细胞或其子集或前体，多肽，载体多核苷酸，宿主细胞，转基因植物，转基因非人类动物，提取物，化合物或多肽的制备方法，富集的树突状细胞群和/或前体扩增的树突状细胞群和/或其前体，鉴定与多肽结合的分子并筛选与多肽结合的化合物的方法，多肽，多核苷酸，载体，宿主细胞，转基因植物，提取物，细胞群的用途和/或构图。，化合物的生产方法和试剂盒。

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8. Poster session 2Morphogenetic mechanisms290MiR-133 regulates retinoic acid pathway during early cardiac chamber specification291Bmp2 regulates atrial differentiation through miR-130 during early heart looping formationDevelopmental genetics294Association of deletion allele of insertion/deletion polymorphism in alpha 2B adrenoceptor gene and hypertension with or without type 2 diabetes mellitus295Association of G1359A polymorphism of the endocannabinoid type 1 receptor (CNR1) with coronary artery disease (CAD) with type 2 diabetes mellitusCell growth, differentiation and stem cells - Vascular298Gamma-secretase inhibitor prevents proliferation and migration of ductus arteriosus smooth muscle cells: a role of Notch signaling in postnatal closure of ductus arteriosus299Mesenchymal stromal-like cells (MLCs) derived from induced pluripotent stem (iPS) cells: a promising therapeutic option to promote neovascularization300Sonic Hedgehog promotes mesenchymal stem cell differentiation to vascular smooth muscle cells in cardiovacsular disease301Proinflammatory cytokine secretion and epigenetic modification in endothelial cells treated LPS-GinfivalisCell death and apoptosis - 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Vascular320Effect of gastrin-releasing peptide (GRP) on vascular inflammationSignal transduction - Heart323A new synthetic peptide regulates hypertrophy in vitro through means of the inhibition of nfkb324Inducible fibroblast-specific knockout of p38 alpha map kinase is cardioprotective in a mouse model of isoproterenol-induced cardiac hypertrophy325Regulation of beta-adrenoceptor-evoked inotropic responses by inhibitory G protein, adenylyl cyclase isoforms 5 and 6 and phosphodiesterases326Binding to RGS3 and stimulation of M2 muscarinic acetylcholine receptors modulates the substrate specificity of p190RhoGAP in cardiac myocytes327Cardiac regulation of post-translational modifications, parylation and deacetylation in LMNA dilated cardiomyopathy mouse model328Beta-adrenergic regulation of the b56delta/pp2a holoenzyme in cardiac myocytes through b56delta phosphorylation at serine 573Nitric oxide and reactive oxygen species - Vascular331Oxidative stress-induced miR-200c disrupts the regulatory loop among SIRT1, FOXO1 and eNOS332Antioxidant therapy prevents oxidative stress-induced endothelial dysfunction and Enhances Wound Healing333Morphological and biochemical characterization of red blood cell in coronary artery diseaseCytoskeleton and mechanotransduction - Heart336Novel myosin activator, JSH compounds, increased myocardial contractility without chronotropic effect in ratsExtracellular matrix and fibrosis - Vascular339Ablation of Toll-like receptor 9 causes cardiac rupture after myocardial infarction by attenuating proliferation and differentiation of cardiac fibroblasts340Altered vascular remodeling in the mouse hind limb ischemia model in Factor VII activating protease (FSAP) deficiencyVasculogenesis, angiogenesis and arteriogenesis343Pro-angiogenic effects of proly-hydroxylase inhibitors and their potential for use in a novel strategy of therapeutic angiogenesis for coronary total occlusion344Nrf2 drives angiogenesis in transcription-independent manner: new function of the master regulator of oxidative stress response345Angiogenic gene therapy, despite efficient vascular growth, is not able to improve muscle function in normoxic or chronically ischemic rabbit hindlimbs -role of capillary arterialization and shunting346Effect of PAR-1 inhibition on collateral vessel growth in the murine hind limb model347Quaking is a key regulator of endothelial cell differentiation, neovascularization and angiogenesis348"Emerging angiogenesis" in the chick chorioallantoic membrane (CAM). An in vivo study349Exosomes from cardiomyocyte progenitor cells and mesenchymal stem cells stimulate angiogenesis in vitro and in vivo via EMMPRINEndothelium352Reciprocal regulation of GRK2 and bradykinin receptor stimulation modulate Ca2+ intracellular level in endothelial cells353The roles of bone morphogenetic proteins 9 and 10 in endothelial inflammation and atherosclerosis354The contribution of GPR55 to the L-alpha-lysophosphatidylinositol-induced vasorelaxation in isolated human pulmonary arteries355The endothelial protective ACE inhibitor Zofenoprilat exerts anti-inflammatory activities through H2S production356A new class of glycomimetic drugs to prevent free fatty acid-induced endothelial dysfunction357Endothelial progenitor cells to apoptotic endothelial cell-derived microparticles ration differentiatesas preserved from reduced ejection fractionheart failure358Proosteogenic genes are activated in endothelial cells of patients with thoracic aortic aneurysm359Endothelin ETB receptors mediate relaxing responses to insulin in pericardial resistance arteries from patients with cardiovascular disease (CVD)Smooth muscle and pericytes362CX3CR1 positive myeloid cells regulate vascular smooth muscle tone by inducing calcium oscillations via activation of IP3 receptors363A novel function of PI3Kg on cAMP regulation, role in arterial wall hyperplasia through modulation of smooth muscle cells proliferation364NRP1 and NRP2 play important roles in the development of neointimal hyperplasia in vivo365Azithromycin induces autophagy in aortic smooth muscle cellsCoagulation, thrombosis and platelets368The real time in vivo evaluation of platelet-dependent aldosterone prothrombotic action in mice369Development of a method for in vivo detection of active thrombi in mice370The antiplatelet effects of structural analogs of the taurine chloramine371The influence of heparin anticoagulant drugs on functional state of human platelets372Regulation of platelet aggregation and adenosine diphosphate release by d dimer in acute coronary syndrome (in vitro study)Oxygen sensing, ischaemia and reperfusion375Sirtuin 5 mediates brain injury in a mouse model of cerebral ischemia-reperfusion376Abscisic acid: a new player in cardiomyocyte protection from ischaemia?377Protective effects of ultramicronized palmitoylethanolamide (PEA-um) in myocardial ischaemia and reperfusion injury in vivo378Identification of stem cell-derived cardiomyocytes using cardiac specific markers and additional testing of these cells in simulated ischemia/reperfusion system379Single-dose intravenous metformin treatment could afford significant protection of the injured rat kidney in an experimental model of ischemia-reperfusion380Cardiotoxicity of long acting muscarinic receptor antagonists used for chronic obstructive pulmonary disease381Dependence antioxidant potential on the concentration of amino acids382The impact of ischemia-reperfusion on physiological parameters,apoptosis and ultrastructure of rabbit myocardium with experimental aterosclerosisMitochondria and energetics385MicroRNA-1 dependent regulation of mitochondrial calcium uniporter (MCU) in normal and hypertrophied hearts386Mitochondrial homeostasis and cardioprotection: common targets for desmin and aB-crystallin387Overexpression of mitofusin-2 (Mfn2) and associated mitochondrial dysfunction in the diabetic heart388NO-dependent prevention of permeability transition pore (MPTP) opening by H2S and its regulation of Ca2+ accumulation in rat heart mitochondria389G protein coupled receptor kinase 2 (GRK2) is fundamental in recovering mitochondrial morphology and function after exposure to ionizing radiation (IR)Gender issues392Sex differences in pulmonary vascular control; 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