METHODS AND COMPOSITIONS FOR PROGNOSTICATIONS AND/OR CLINICAL MANAGEMENT OF GRAFT-VERSUS-HOST DISEASE AND TRANSPLANT REJECTION

摘要

Compositions and methods are provided to determine the likelihood of a subject to develop a complication resulting from an adaptive immune response upon receiving an organ or tissue transplantation. The likelihood is based on expression or activity levels of suppressor of fused (SUFU) mRNA and/or SUFU protein. Such methods and compositions find use in enabling personalized prophylactic or therapeutic treatment regimens for subject based on assessed risk.