NEW INDUSTRIAL CRYSTALLISATION METHOD FOR CEFUROXIME SODIUM AND PREPARATION THEREOF

摘要

Disclosed is a new industrial crystallisation technique for cefuroxime sodium, wherein a supercritical fluid extraction technique is combined with conventional crystallization techniques to realize the recrystallization of cefuroxime sodium. Within the whole crystallization system, under the conditions of a specific temperature and pressure, the processes of extraction, adsorption, crystallization and drying are done so as to realize the recrystallization of cefuroxime sodium with the combined action of a supercritical fluid, a solvent, an extraction pool and a crystallizing pool. The present method has a high separation efficiency and few impurities, and greatly improves the quality of preparation products.