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RNA guided eradication of human JC virus and other polyomaviruses
RNA guided eradication of human JC virus and other polyomaviruses
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机译:RNA指导消灭人类JC病毒和其他多瘤病毒
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摘要
The present invention includes methods and compositions for elimination of polyomaviruses, such as John Cunningham Virus (JVC), from host cells, and the treatment of polyomavirus related diseases, such as progressive multifocal leukoencephalopathy (PML). The compositions include isolated nucleic acid sequences comprising a CRISPR-associated endonuclease and a guide RNA, wherein the guide RNA is complementary to a target sequence in a polyomavirus.
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