Variable new antigen receptors (VNARs) directed against transferrin receptor (TfR) and their use

摘要

This invention relates TfR-specific binding moieties with high specificity for and functional interaction with the transferrin receptor ("TfR"). These moieties may be used to carry biomolecules across membranes, including the blood brain barrier and the gastrointestinal tract. The invention relates more specifically to nurse shark VNAR single chain antibodies that bind to TfR, conjugates and compositions comprising a TfR specific VNAR binding moiety, methods for preparing them, diagnostic and therapeutic methods of use