FORMULATION METHODS AND OINTMENT FORMULATIONS THEREIN CONTAINING URACIL, THYMINE, AND/OR THEIR DERIVATIVES FOR TREATMENT AND PREVENTION OF HAND-AND-FOOT SYNDROME

摘要

The present invention discloses formulation methods and ointment formulations therein containing uracil, thymine, and/or their derivatives for treatment and prevention of hand-and- foot syndrome. Formulations include: a skin agent having a solubilized solution of uracil and/or thymine; and a mixture containing at least one type of material selected from the group consisting of: a water-dispersible lipid and a lipophilic substance, wherein the solution is homogeneously dispersed in the mixture in an effective final concentration of the uracil and/or the thymine. Alternatively, the solution is selected from the group consisting of: a glycerol- based solution and a propylene glycol-based solution. Alternatively, the skin agent is selected from the group consisting of: a hand cream, a foot cream, a face cream, a body cream, an ointment, and a skin lotion. Alternatively, the uracil includes uracil derivatives, and wherein the thymine includes thymine derivatives.