Selective methylation reagent p-toluene sulfonic acid methyl ester synthesis method

摘要

#$%^&*AU2016102175A420170216.pdf#####ABSTRACT Selective methylation reagent p-toluene sulfonic acid methyl ester synthesis method, comprising the following steps: equipped with a stirrer, a thermometer, a dropping funnel, a reaction vessel, was added 0.271mol p-toluenesulfonyl bromine (2), 1.57-1.59mol 2,2,2- trifluoroethyl methyl ether, controlling stirring speed at 160-190rpm, temperature controlled at 35--40'C, 300ml potassium carbonate solution was added, the dropping time was controlled in 2-3h, after addition maintaining the stirring for 5-6h, the oil was separated, washed with salt solution, sodium sulfite solution, dimethylamine solution successively, dehydrated with dehydrating agent, vacuum distillation, collecting the distillate of 140--145 C, got p-toluene sulfonic acid methyl ester.