Cephalothin drug intermediates 2-acetyl thiophene synthesis method

摘要

#$%^&*AU2016102187A420170216.pdf#####ABSTRACT Cephalothin drug intermediates 2-acetyl thiophene synthesis method, comprising the following steps: equipped with a stirrer, thermometer and a reflux condenser, the reaction vessel was added 2.5-2.7mol thiophene, 0.95 mol acetamide, 200ml hydrochloric acid solution, controlled stirring speed at 130-160rpm, controlled temperature of the solution at 65-70 C, holding 60-90 min, the temperature of the solution is reduced to 50--55 C, reflux for 3-4h, the temperature of the solution is reduced to 10 - 15 C, washed with 400ml sodium chloride solution, and then washed with sodium sulfite solution, dried with activated alumina and got orange-red liquid, fractionation, first distilled thiophene, vacuum distillation, collecting 95--100 C fractions, got 2-acetyl thiophene.