#$%^&*AU2016102278A420170223.pdf#####ABSTRACT Gastrodin pharmaceutical intermediate 4-formylphenyl-2,3,4,60- acetyl -P -D- glucopyranose glucoside , comprising the following steps: the reaction vessel was added 0.062mola - substituting acetyl glucopyranosyl amine (2), 210ml toluene solution, 0.071-0.073mol hydroxybenzaldehyde (3) was dissolved 0.16mol sodium bisulfite solution, the two solutions were mixed, the solution temperature is raised to 40-45 C, allowed to stand for 30-36 h, toluene was distilled off under reduced pressure, the temperature of the solution is reduced to 10 15 C, the oil layer was separated, washed with potassium chloride solution for 9-11 times, added 300ml p-xylene solution, the solution temperature is raised to 60-65 C, maintain 60-90min, after decolorization with zeolite, the temperature of the solution is reduced to 3 - 5 C , to maintain 30-35h, white needle crystals was precipitated, filtered, washed with salt solution, washed with cyclohexane solution, dehydrated with dehydrating agent, recrystallized in nitroethane solution, got crystals 4-formylphenyl-2,3,4,6- 0- acetyl -P -D- glucopyranose glucoside .
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