Fluorouracil drug intermediates 1-benzyl-5-amino uracil phthalocyanine synthesis method

摘要

#$%^&*AU2016102282A420170223.pdf#####ABSTRACT Fluorouracil drug intermediates 1 -benzyl-5 -amino uracil phthalocyanine synthesis method, comprising the following steps: equipped with a stirrer, thermometer and reflux condenser, the reaction vessel was added 0.23mol 1-amino-phthalide (2), 0.26-0.28mol 5-aminouracil, 0.31mol stannous chloride, 230ml cyclohexane solution, controlled stirring speed at 130-170 rpm, 0.13 mol sodium sulfite solution was added in batches, stirred for 5-7 h, filtered, and the filtrate was concentrated under reduced pressure , distilled off the cyclohexane, 630ml potassium chloride solution was added, the precipitated solid was filtered, washed with saline solution, dehydrated with dehydrating agent, added into acetonitrile solution, the solution temperature is raised to 60-65 C, after 60-80min, filtration, recrystallized from nitromethane solution, got crystals of 1 -benzyl-5-amino uracil phthalocyanine .