METHOD TO USE VIRAL AND HOST METHYLATION MARKERS FOR CERVICAL CANCER SCREENING AND TRIAGE IN LIQUID PREP, SERUM/PLASMA, AND URINE: PCR AND SEQUENCING BASED PROCESS METHODS

摘要

Methods and kits for triaging a human papillomavirus (HPV)-positive woman into colposcopy are disclosed. The methods comprise determining the promoter methylation level of the promoter regions of a group of genes (e.g., viral and host genes) that exhibit increased promoter methylation in women having CIN2+ lesions as compared to women having no intraepithelial lesions or malignancy (NILM).