PERIOSTIN GENE EXPRESSION-SUPPRESSING NUCLEIC ACID MOLECULE, METHOD FOR SUPPRESSING EXPRESSION OF PERIOSTIN GENE, AND APPLICATION THEREFOR

摘要

Provided is a novel molecule for suppressing expression of the periostin gene. A nucleic acid molecule for suppressing expression of the periostin gene, wherein the expression-suppressing nucleic acid molecule is characterized in containing the following (as4) nucleotide as a periostin-gene-expression-suppressing sequence. (as4) A nucleotide having the ability to suppress expression of the periostin gene, said nucleotide comprising a base sequence that hybridizes under stringent conditions with a polynucleotide comprising any base sequence of SEQ ID NOS: 121-127. Since this expression-suppressing nucleic acid molecule can suppress expression of the periostin gene, said molecule can be used, for example, in the treatment of diseases resulting from periostin gene expression.