METHODS AND DEVICE FOR PHENOTYPIC CLASSIFICATION OF CELLS BASED ON MIGRATORY BEHAVIOR

摘要

The present invention provides a device and methods that allow time-resolved studies of migration with single-cell resolution on a fibrillary surface that mimics in vivo migration of cells. This platform is utilized for a high-content screen of patient-specific glioblastoma samples to analyze heterogeneities in the phenotype of migratory cells. The information the platform provides has prognostic value as it shows significant differences in time to recurrence and tumor location based on phenotypic classifiers.