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COMPOSITION AND EUTECTIC OF SAXAGLIPTIN AND METFORMIN, AND PREPARATION METHOD AND USE THEREOF
COMPOSITION AND EUTECTIC OF SAXAGLIPTIN AND METFORMIN, AND PREPARATION METHOD AND USE THEREOF
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机译:沙格列汀和二甲双胍的组成,共晶及其制备方法和用途
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摘要
The present invention relates to a composition and eutectic of saxagliptin and metformin, and a preparation method and use thereof. In particular, provided in the present invention are a composition and a eutectic form in which the molar ratio of saxagliptin and metformin is 1:1, wherein the X-ray powder diffraction pattern (CuK α radiation) of eutectic crystal form I thereof has characteristic peaks at 2 theta values of 17.8° ± 0.2°, 6.6° ± 0.2° and 22.4° ± 0.2° at 25ºC. The composition and eutectic provided in the present invention have good stability, low wettability, and a solubility meeting the medicinal requirements, all of which are of great value for the optimization and development of the drug in the future.
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