TEST METHOD FOR DETERMINING THROMBOLYTIC DRUGS INDIVIDUALIZED DOSAGE IN VITRO

摘要

Disclosed is a test method for determining a thrombolytic drug individualized dosage in vitro, comprising drawing venous blood of a checked patient, separately adding the blood into eight rotating rings, with no. 1 being an empty ring, no. 2 being physiological saline, and no. 3 to 8 being low to high concentrations of thrombolytic agents. Putting the eight rotating rings into a blood mixer, starting the mixer, taking the rotating rings out of the mixer, taking out a thrombus and residual blood formed in the rotating rings and putting them on the surface of the filter paper, sequentially observing the morphology, size and weight of thrombi taken from the rotating rings, recording the thrombus as formed above with the smallest volume and weight or the concentration of the thrombolytic drug corresponding to the time point without thrombosis, and according to the equation: dose of the intravenous thrombolytic drug = 2/3 × weight × concentration of thrombolytic drug, calculating the dosage for the checked patient. The method can both determine the effective thrombolysis of the checked patient and avoid bleeding and other complications, thereby guiding intravenous thrombolytic treatment of a patient with acute heart and cerebral infarctions.