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METHODS FOR PRODUCING HYPO-ALLERGENIC CATS USING GENE EDITING TECHNOLOGY
METHODS FOR PRODUCING HYPO-ALLERGENIC CATS USING GENE EDITING TECHNOLOGY
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机译:利用基因编辑技术生产低变应性猫的方法
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摘要
A genetically modified cat produced through gene editing with a phenotype characterized by the substantial absence of the major cat allergen, Fel d I. The phenotype is conferred in the genetically modified cat by targeting either the gene sequence of the Fel d I locus or sequences flanking the coding sequence of the two contiguous Fel d I genes with specialized gene editing constructs. The genotype and phenotype of the genetically modified cat is transmissible to its offspring.
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机译:通过基因编辑产生的转基因猫,其表型的特征是基本上不存在主要的猫过敏原Fel dI。通过对Fel d I基因座的基因序列或侧翼序列进行靶向,该表型在转基因猫中产生具有专门的基因编辑构建体的两个连续Fel d I基因的编码序列。转基因猫的基因型和表型可遗传给其后代。
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