首页> 外国专利> KIT AND METHOD FOR SELECTING CANCER PATIENTS FOR WHOM ADMINISTRATION OF ANTIBODY PHARMACEUTICAL FOR HER2 PROTEINS, WHICH ARE THERAPEUTIC TARGET MOLECULES, IS EFFECTIVE

KIT AND METHOD FOR SELECTING CANCER PATIENTS FOR WHOM ADMINISTRATION OF ANTIBODY PHARMACEUTICAL FOR HER2 PROTEINS, WHICH ARE THERAPEUTIC TARGET MOLECULES, IS EFFECTIVE

机译:有效治疗HER2蛋白质的抗体和抗体的选择方法及针对癌症药物的整体管理的有效药物

摘要

The present invention provides a kit and a method for selecting cancer patients for whom the administration of an antibody pharmaceutical for HER2 proteins, which are therapeutic target molecules, is effective. The kit contains a lateral flow immunoassay test strip that has a structure in which there are connected, in sequence from the upstream side in the direction of sample flow, a sample pad where a sample is added, a conjugate pad that holds first anti-HER2 protein antibodies, a membrane that has a region where second anti-HER2 protein antibodies and antibodies that bind to the first anti-HER2 protein antibodies are immobilized, and an absorbent pad, wherein an antibody pharmaceutical for HER2 proteins, which are therapeutic target molecules, is used for either of the first anti-HER2 protein antibodies and the second anti-HER2 protein antibodies. The method according to the present invention includes a step for detecting HER2 proteins in the cancer tissue of a patient by lateral flow immunoassay using this test strip.
机译:本发明提供了用于选择癌症患者的试剂盒和方法,对于所述癌症患者,有效治疗HER2蛋白的抗体药物(作为治疗靶分子)的给药是有效的。该试剂盒包含侧向流动免疫测定试纸条,该试纸条具有以下结构:在该结构中,从上游向样品流动方向依次连接有添加样品的样品垫,装有第一抗-HER2的结合物垫蛋白抗体,具有固定有第二抗HER2蛋白抗体和与第一抗HER2蛋白抗体结合的抗体的区域的膜和吸收垫,其中吸收剂是用于治疗靶分子的HER2蛋白的药物,第一抗-HER2蛋白抗体和第二抗-HER2蛋白抗体中的任一个被使用。根据本发明的方法包括使用该试纸条通过侧向流免疫测定法检测患者癌症组织中的HER2蛋白的步骤。

著录项

  • 公开/公告号WO2017131066A1

    专利类型

  • 公开/公告日2017-08-03

    原文格式PDF

  • 申请/专利权人 KYOTO UNIVERSITY;

    申请/专利号WO2017JP02645

  • 发明设计人 MUTO MANABU;YOSHIOKA MASAHIRO;

    申请日2017-01-26

  • 分类号G01N33/574;A61K39/395;A61P35;G01N33/543;

  • 国家 WO

  • 入库时间 2022-08-21 13:30:13

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