PH RESPONSIVE FLUORESCENT COMPOUND, COMPOSITION FOR DETECTING MITOPHAGY USING SAME, AND METHOD FOR DETECTING MITOPHAGY WITHIN CELLS

摘要

Disclosed is a pH-responsive fluorescent compound, represented by the general formula, which is a novel pH-responsive fluorescent compound capable of being specifically localized in mitochondria within cells, which exhibits strong fluorescence under weakly acidic pH environments in lysosomes, and which is not readily subject to interference from autofluorescence and background fluorescence due to other fluorescent substances within cells. Also disclosed are a composition for detecting mitophagy using the pH-responsive fluorescent compound, and a method for detecting mitophagy within cells. In the general formula, L represents a linker, X represents a pharmaceutically acceptable anion, and Y represents a reactive functional group that is covalently bondable with a functional group on a mitochondrial protein.