MUTATION OF CANDIDA ALBICANS AND USE IN TREATMENT AGAINST CANDIDIASIS

摘要

The invention relates to mutations of Candida albicans lacking functional copies of their PIR1 gene, preferably via deletion in all the copies thereof, as well as a method for producing same. Said mutations are attenuated strains that do not cause candidiasis symptoms, but do provide protection against same when injected into an animal prior to infection with an infectious strain. The invention comprises the use of said mutations to trigger a protective response against candidiasis, or specifically as live attenuated vaccines, in particular against disseminated candidiasis.