USE OF ANTI-MCAM ANTIBODIES FOR TREATMENT OR PROPHYLAXIS OF GRANULOMATOUS LUNG DISEASES

摘要

The invention provides anti-MCAM antibodies that inhibit the ability of human MCAM to bind a laminin alpha-4 chain and pharmaceutical compositions and pharmaceutical formulations incorporating the same for use in treatment or prophylaxis of chronic beryllium disease (CBD), Blau syndrome or hot tub lung disease, methods of generating such antibodies, and their use in the manufacture of medicaments for treatment of granulomatous lung diseases.