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MASS SPECTROMETER AND BIOLOGICAL SAMPLE ANALYSIS METHOD USING SAID MASS SPECTROMETER

机译:所述质谱仪的质谱仪和生物样品分析方法

摘要

In the present invention, in a PESI ion source, a solvent supply unit (8) is placed over a liver (101) to be measured and a sample is collected at the leading end of a probe (6) through the vertical movement of the probe (6) such that the leading end passes through the solvent supply unit (8) and pierces the liver (101). The solvent supply unit (8) includes: a container part in which a liquid-impermeable upper film body (81) is provided on the bottom opening of a cylindrical body (80) so as to be stretched; and a liquid-impermeable lower film body (82) that is provided so as to be stretched and so as to be roughly parallel to the upper film body (81) with a spacer disposed therebetween. A solvent (84) is accommodated in the container part. Because the leading end of the probe (6) passes through the solvent (84) when the probe (6) is moved vertically, the solvent adheres sufficiently to the sample, and components in the sample are satisfactorily ionized when high voltage is applied to the probe (6). Blood that leaks upward from the liver (101) through the hole through which the probe (6) was inserted spreads in the vicinity of the lower film body (82) and does not mix with the solvent (84) in the container part. As a result, it is possible to avoid contamination by blood during measurement.
机译:在本发明中,在PESI离子源中,将溶剂供应单元(8)放置在要测量的肝脏(101)上,并通过探头(6)的垂直移动在探头(6)的前端收集样品。探头(6)使其前端穿过溶剂供应单元(8)并刺穿肝脏(101)。溶剂供应单元(8)包括:容器部分,其中在圆筒体(80)的底部开口上设置有不透液的上膜体(81)以被拉伸;透液性的下膜主体(82)被设置成可拉伸并大致平行于上膜主体(81),并在其间设置有间隔物。溶剂(84)容纳在容器部分中。由于在垂直移动探针(6)时探针(6)的前端会穿过溶剂(84),因此当对样品施加高压时,溶剂会充分粘附到样品上,并且样品中的成分会令人满意地离子化。探针(6)。从肝脏(101)通过插入有探针(6)的孔向上方泄漏的血液在下膜体(82)附近扩散,在容器部不与溶剂(84)混合。结果,可以避免在测量期间被血液污染。

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