DEFORMABLE REGISTRATION OF INTRA AND PREOPERATIVE INPUTS USING GENERATIVE MIXTURE MODELS AND BIOMECHANICAL DEFORMATION

摘要

A computer-implemented method of performing registration of preoperative and intraoperative image data includes receiving a first three-dimensional model of an anatomical area of interest derived from one or more image volumes acquired in a preoperative setting and acquiring images of the anatomical area of interest in an operative setting using an intraoperative image acquisition device. A second three-dimensional model of the anatomical area of interest is generated using the images. Next, the first three-dimensional model is aligned with the second three-dimensional model using a rigid registration process. Then, an iterative deformable registration process is performed to further align the two three-dimensional models. This iterative deformable registration process may include, for example, computing a generative mixture model representative of the second three-dimensional model, using the generative mixture model to derive physical force vectors, and biomechanically deforming the first three-dimensional model toward the second three-dimensional model using the physical force vectors.