A system, method and apparatus are provided for detecting the presence of an analyte and / or determining the concentration of an analyte. An analyte may be provided on the LSPR-active surface. The LSPR-active surface may include a sensitivity enhancement label. The analyte can induce local changes near the LSPR-active surface. The LSPR-active surface can be imaged using imaging equipment before, during, or after the reaction occurs. The local area of interest in the image can be analyzed to detect local changes.
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