METHODS COMPOSITIONS USES AND KITS USEFUL FOR VITAMIN D DEFICIENCY AND RELATED DISORDERS

摘要

Methods of diagnosis, treatment and prevention of vitamin D deficiency associated with catabolism and related diseases; Related compositions, devices and kits are disclosed. Said method comprising the steps of measuring a CYP24 expression and / or activity, or a surrogate thereof, such as a level of FGF23, in a patient, and measuring an abnormally increased CYP24 expression and / or activity in relation to a catabolic vitamin D deficiency or catabolism-related vitamin D deficiency Lt; RTI ID = 0.0 susceptibility. / RTI For an abnormally increased CYP24 expression and / or activity, the method comprises administering a CYP24 inhibitor to a vitamin D deficient or a risk patient, and preferably, by avoiding administration of an active vitamin D compound to such a patient, D binding receptor. Optionally, a pre-vitamin D hormone or pro-hormone may be administered.