Useful methods, compositions, uses and kits for vitamin D deficiency and related disorders

摘要

A pharmaceutical formulation for use in a method of treatment or prevention of vitamin D deficiency related to catabolism, in a patient who has chronic kidney disease, the deficiency being defined by a total serum level of 25-hydroxyvitamin D below 30 ng / ml, the composition comprising an effective amount of a CYP24 inhibitor selected from the group consisting of (R) -N- (2- (1H-imidazol-1-yl) -2-phenylethyl) -4'-chlorobiphenyl- 4-carboxamide, ketoconazole, metronidazole, clomethiazole, itraconazole, fluconazole, compounds 23,23-difluoro-24-sulfone vitamin D3, compounds 25-sulfone vitamin D3, compounds 24,24-difluoro-25-sulfone vitamin D3, 24-sulfoximin vitamin D3 compounds, 16-eno-25-oxime vitamin D3 compounds, 16-eno-25-oxime ether vitamin D3 compounds, 24-sulfone vitamin D3 compounds, 24,24-difluoro vitamin D3 compounds and combinations thereof.