RNA NMDA Method of determining function decreases repressing function decreases and screeing function decreases inhibition of hippocampus using correlation of micro RNA and NADA receptor

摘要

The present invention relates to a method for determining functional degradation of hippocampus by using correlation of microRNA (miRNA) and an N-methyl-D-aspartate receptor (NMDAR), a method for controlling functional degradation, and a method for screening a functional degradation inhibitor. According to the present invention, miR-204 from miRNA adjusted to increase in aged hippocampus reduces EphB2 expression by accurately targeting EphB2 which is an important adjustment receptor. Thus, neuron surface expression of an NR1 sub-unit of an NMDAR of hippocampus nerves is reduced, and it has been confirmed that a decrease in neurodendrite density is caused. Accordingly, functional degradation of hippocampus is determined by using correlation of miRNA and an NMDAR, and functional degradation of hippocampus is controlled.