A novel fusion protein having cell adhesion activity and osteogenic differentiation activity

摘要

The present invention relates to a fibronectin fusion protein that binds to the domain 10 of the type 3 fibronectin and has an activity of promoting cell adhesion and promoting bone differentiation, a polynucleotide encoding the fusion protein, a fusion protein comprising the polynucleotide A method for producing the fusion protein using the transformant, a method for attaching the cell using the fusion protein, a method for producing the fusion protein using the fusion protein, a method for producing the fusion protein using the fusion protein, The present invention relates to a pharmaceutical composition for preventing or treating bone diseases, which comprises a protein, and a pharmaceutical composition for bone or tooth regeneration comprising the fusion protein. Since the fusion protein of the present invention includes the type 3 fibronectin domain 10 and the self-assembling sequence, it has been confirmed that it can activate various cell activities such as cell binding, cell proliferation and osteogenesis differentiation more than the fibronectin protein, It may be widely used not only to prevent or treat bone diseases, but also to regenerate damaged bone or teeth.