TREM-1 SITE DIRECTED MUTAGENESIS OF TREM-1 ANTIBODIES FOR DECREASING VISCOSITY

摘要

Antibodies that specifically bind to TREM-1, a protein expressed on monocytes, macrophages and neutrophils, which have both good affinity and low viscosity at clinically relevant concentrations, are capable of preventing its activation. Such antibodies are useful in the treatment of inflammatory diseases, such as those suffering from rheumatoid arthritis and inflammatory bowel disease.