GLP-1R GLP-2R COMPOSITIONS AND PEPTIDES HAVING DUAL GLP-1R AND GLP-2R AGONIST ACTIVITY

摘要

The present invention is a composition having agonist activity for the GLP-2 receptor of the GLP-1 receptor and the human the human and peptides, as well as relates to its manufacturing method and use, the relative of the dual peptide of the GLP-1 receptor of human agonist activity (GLP-1R _relative) is at least 0.01, and wherein the relative agonist activity of the dual peptide of the GLP-2 receptor of human (GLP-2R _relative) is at least 0.01, and (GLP-1R _relative) (GLP-2R _relative) is at least 0.01. The invention also relates to analogues of the peptide lipid screen. The present invention also relates to a therapeutic or prophylactic treatment of diseases of the people, especially the brain and related diseases, or metabolic disorders such as gastrointestinal inflammation, short bowel syndrome and Crohn's disease.