CD73 BINDING MOLECULES SPECIFIC FOR CD73 AND USES THEREOF

摘要

This disclosure provides anti-CD73 binding molecules, such as antibodies and antigen-binding fragments thereof. Also provided are pharmaceutical formulations comprising the disclosed compositions and methods of diagnosing and treating diseases associated with CD73 expression, such as cancer. Such diseases include, for example, direct treatment with the anti-CD73 binding molecules disclosed herein (e. G., Naked antibodies or antibody-drug conjugates binding to CD73), immunotherapeutic agents such as anti-CTLA- CD73 molecule is administered prior to, after, or concurrently with chemotherapy, and / or by adjuvant therapy with other antigen-binding chemotherapeutic agents such as anti-PD-1 monoclonal antibodies and / or anti-CD73 molecules.