HPV16 THERAPEUTIC HPV16 VACCINES

摘要

The present invention provides designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV 16. These polypeptides essentially contain all possible T-cell epitopes of the HPV 16 tumor proteins E6 and E7, but nevertheless contain a minimal number of undesired neo-epitopes, as well as fragments of rearranged E6 and E7 proteins (Compared to wt E6 and E7), to a degree of non-detectable transformation activity. The invention provides a nucleic acid molecule encoding a polypeptide comprising the sequence set forth in SEQ ID NO: 1. In certain embodiments, the encoded polypeptide further comprises at least one epitope of a human papilloma virus (HPV) E2 protein, e. G. HPV 16 E2 protein.