46--15-a46-SUBSTITUTED-PYRAZOLO15-aPYRAZINES AS JANUS KINASE INHIBITORS

摘要

A compound of formula (I) And stereoisomers and pharmaceutically acceptable salts and solvates thereof, wherein R ¹ , R ² , R ³ and R ⁴ have the meanings given in the description, are inhibitors of one or more of the JAK kinases, Disorders, such as autoimmune diseases, inflammatory diseases, grafted organs, rejection of tissues and cells, and hematologic disorders and malignant tumors, and coexisting infections thereof.