HLA- METHOD FOR THE ABSOLUTE QUANTIFICATION OF NATURALLY PROCESSED HLA-RESTRICTED CANCER PEPTIDES

摘要

The present invention relates to a method for absolute quantification of naturally processed HLA-restricted cancer peptides, i. E. Determination of the number of copies of peptides presented per cell. The present invention can be used not only for the development of antibody therapies or peptide vaccines, but also for vaccines and antibody-based therapies in cancer, infectious and / or autoimmune diseases, which are highly valuable for molecularly defined immune- It is also useful for identification of new peptide antigens for immunotherapy strategies such as adoptive T-cell metastasis approach.