The present invention relates to a composition and a method for predicting a treatment response to an attention-deficit hyperactivity disorder medicine. One aspect provides a composition comprising a reagent capable of detecting rs2284411 polymorphic site of a polynucleotide encoding a glutamate receptor, ionotropic, N-methyl D-aspartate 2B (GRIN2B) for predicting responsiveness to methylphenidate treatment in a subject having attention deficit hyperactivity disorder. Another aspect provides a method for predicting responsiveness to methylphenidate treatment in a subject having attention deficit hyperactivity disorder, and a method for selecting a subject having possibilities of responding to methylphenidate treatment among subjects having attention deficit hyperactivity disorder.
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