Present invention relates to compositions and methods for predicting response to therapy for ADHD drugs. One aspect is a glutamate receptor Methyl the target having, attention deficit hyperactivity disorder comprising a reagent capable of detecting the rs2284411 polymorphism in a polynucleotide encoding the (glutamate receptor, ionotropic, N-methyl D-aspartate 2B GRIN2B) It provides a composition for predicting the responsiveness to therapy penny date. Provides a way to select the destination has the possibility to respond to methylphenidate treatment in another aspect the target with a method of predicting responsiveness to methylphenidate treatment in a subject having an attention deficit hyperactivity disorder and attention deficit hyperactivity disorder do.
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