首页> 外国专利> CAENORHABDITIS ELEGANS WITH SPECIFICALLY INHIBITED DEVELOPMENTAL DEFECTS OF INSULIN/IGF-1 RECEPTOR DEFICIENT MUTANT

CAENORHABDITIS ELEGANS WITH SPECIFICALLY INHIBITED DEVELOPMENTAL DEFECTS OF INSULIN/IGF-1 RECEPTOR DEFICIENT MUTANT

机译：具有特定抑制胰岛素/ IGF-1受体缺失突变体发育缺陷的食蟹猴

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摘要

The present invention relates to: Caenorhabditis elegans having insulin/IGF-1 receptor deficient mutant which maintains immunity and inhibits developmental defects; a manufacturing method thereof; and a method for screening a candidate treatment agent of insulin/IGF-1 signal transduction diseases using the Caenorhabditis elegans. A PTEN^C150Y mutant Caenorhabditis elegans animal model provided in the present invention can specifically reduce developmental defects without affecting excellent immunity of an existing insulin/IGF-1 receptor deficient mutant, thereby obviously identifying how immunity, aging, development are each controlled in an insulin/IGF-1 signal transduction system. Moreover, according to the present invention, it is expected that the present invention can contribute greatly to various research fields such as immunity enhancement and anti-aging drug development related to the insulin/IGF-1 signal transduction system.;COPYRIGHT KIPO 2017

机译：本发明涉及具有胰岛素/ IGF-1受体缺陷型突变体的秀丽隐杆线虫，该突变体维持免疫力并抑制发育缺陷。其制造方法;以及使用秀丽隐杆线虫筛选胰岛素/ IGF-1信号转导疾病的候选治疗剂的方法。本发明提供的PTEN ^ C150Y突变体秀丽隐杆线虫动物模型可以特异性地减少发育缺陷而不影响现有胰岛素/ IGF-1受体缺陷型突变体的优异免疫力，从而明显地确定了如何在胰岛素中分别控制免疫力，衰老，发育。 / IGF-1信号转导系统。此外，根据本发明，期望本发明可以在与胰岛素/ IGF-1信号转导系统相关的诸如免疫力增强和抗衰老药物开发的各种研究领域中做出巨大贡献。; COPYRIGHT KIPO 2017

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公开/公告号KR20170104019A

专利类型
公开/公告日2017-09-14

原文格式PDF
申请/专利权人 POSTECH ACADEMY-INDUSTRY FOUNDATION;
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申请/专利号KR20160025480
发明设计人 OZLEM ALTINTASTR;HWANG WOO SEONKR;LEE SEUNG JAEKR;
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申请日2016-03-03
分类号A01K67/033;G01N33/50;
国家 KR
入库时间 2022-08-21 13:26:41

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