Induced expression of brain-derived neurotrophic factor (BDNF) for the treatment of neuromuscular, neurodegenerative, autoimmune, developmental and / or metabolic diseases

摘要

Neurodegenerative, developmental, autoimmune and metabolic diseases / disorders associated with aging by induction of endogenous BDNF expression in DNP therapy to protect against neuromuscular dysfunction / disorder and / or neural degeneration and / or muscle wasting (MG), rheumatoid arthritis (RA), Graves' disease, schizophrenia, schizophrenia, schizophrenia, schizophrenia, schizophrenia, traumatic injury, stroke, Huntington's disease, epilepsy, multiple sclerosis, lupus, (GBS), metabolic syndrome, muscle dystrophy or dysenteric dystrophy (DMD), severe burns, aging, amyotrophic lateral sclerosis (ALS), Friedrich's Ataxia, Barthen's disease, Alzheimer's disease, optic neuritis, (LHON), autism, Rett syndrome, Barthen's disease, Angelman syndrome, Lyric disease, fragile X syndrome, depression, Parkinson's disease, mitochondrial disease, developmental disorder, metabolic disease disorder and / How to treat a host of disorders Station. DNP was administered to mice in a range of doses on a daily basis, followed by BDNF expression in the brain showing a dose-dependent and non-linear increase in expression.