Zanthoxylum piperitum leaf extracts fractions or compounds isolated therefrom with the effect of anti-inflammatory and analgesic

摘要

The present invention relates to a pharmaceutical composition for treating and preventing arthritis, which comprises a leaf extract of Zanthoxylum piperitum or a compound isolated therefrom, and more particularly to a pharmaceutical composition for treating and preventing arthritis comprising quercetin-3-O-alpha-L - Central and peripheral pain suppression and antiinflammatory effects of Laminocide (Quercitrin) and camphorol-3-O-alpha-L-Laminoside (Afzelin) , And the improvement effect of arthritis based on this was confirmed. Accordingly, the present invention relates to a composition for treating and preventing arthritis based on the effect of improving pain and inflammation, a compound of papaya leaf extract and a compound isolated therefrom, and a process capable of including these components under optimal conditions. In other words, the extracts of papaya leaf, aquaticin and afzelin according to the present invention suppress pain, inflammation and arthritis both in pain induction animal model, inflammation induction model and arthritis induction model, and excellent expression and inhibition And can be used as a pharmaceutical composition highly effective for the treatment of arthritis based on pain and inflammation.