RNA Dicer Substrate RNA Nanostructures for Enhanced Gene Silencing Effect and Process for Preparation Thereof

摘要

The present invention relates to an RNA nanostructure as a dicer substrate ensuring enhanced gene silencing effects, and a production method thereof. The RNA nanostructure contains a plurality of RNA interference (RNAi) sequences which can be the same or different from each other in a single RNA nanostructure, thereby effectively, simultaneously, and selectively regulating expression of a plurality of genes. In addition, by regulating opening or closing state of the RNA nanostructure in the production of the RNA nanostructure, it is possible to intentionally regulate activation of RNAi sequences.